AGA
- Pattern hair loss or androgenic alopecia is a genetically predisposed disorder from altered response to androgen. However, pattern hair loss is seen to occur clinically even with normal androgen levels. Scientific updates have attributed hair loss to be inflammatory, immune-mediated, nutritional, genetic and hormonal or from any imbalance causing dysregulation of the hair growth cycle.
- AGA is described as prolongation of telogen and shortening of anagen. Clinically, every alopecia begins as simple hair fall or telogen effluvium. Continued exposure to these non androgenic factors, promotes gradual cellular dysfunction and accumulation of ROS, which is proven to increase the sensitivity of androgen receptors (AR) making them hyper sensitive to normal circulating androgens, without any rise in androgen levels.
- ROS also trigger the release of inflammatory cytokines which further augment various AR sensitive pathways. Thus, the follicles have now become sensitive to normal androgens and DHT from relentless exposure to non androgenic factors.
- Nutrients are also responsible for secretion of hormones, neurotransmitters, chemical mediators, regulators of cell function, defense and immunity. Inability to keep up to these functions manifests as oxidative stress, compromised immune response, inability to counter inflammation, cellular aging and senescence. Hair being a tissue with a high metabolic rate, even a modest imbalance, affects the growth cycle converting mitosis to apoptosis.
- In conditions of nutrient deficiencies, the body prioritizes short-term survival over long-term health through physiological triage. Evident in redistribution of blood flow to the vital organs in conditions of low oxygen pressure or shock. Triage prioritizes ATP synthesis over DNA-repair, erythrocyte function over leukocytes and neuroendocrine functions over liver enzymes. The high metabolic demand of the hair follicle is subject to triage even under marginal nutrient deficiencies.
Key Ingredients & Roles
With advantages of Quercetin, Lactoferrin, DHA, Beta sitosterols, Egg
shell membrane, MSM(methyl sulphonyl methane) etc.
Beta sitosterols
It is a plant – derived phytosterol, which blocks the conversion
of testosterone in to dihydrotestosterone (DHT) by inhibition of
5 alpha – reductase enzymes and helps in androgenic alopecia.
Its antioxidant activity counters ROS and stress – induced
alopecia. It also modifies prostaglandin pathways and T helper
cell- mediated immune response.
Egg shell
membrane
It improves hair thickness, appearance of hair and shows a
reduction in hair breakage. It also promotes hair growth.
Methyl sulfonyl methane (MSM)
It is a sulfur- rich compound with anti-inflammatory properties.
Sulfur present in MSM strengthens the bond between keratin
molecules which improves hair growth and appearance of hair.
Quercetin
It stimulates hair growth with enhanced expression of growth
factors via activation of MAPK/CREB signaling pathway. It
inhibits the production of DHT from testosterone by blocking the
action of 5 alpha reductase enzymes which prevents balding of
the scalp in AGA.
Lactoferrin
It is an iron -binding glycoprotein found in body fluid
including milk, exerts effects on the stimulation of DP cell
proliferation and hair growth. Lactoferrin shows
anti-inflammatory, immune – boosting properties that prevents
hair loss.
Docosahexanoic acid (DHA)
It is an omega 3 fatty acids that not only increases cellular
proliferation. But also promotes hair growth through the anagen
– activating pathway in DPCS.
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