AGA - Stress
- Pattern hair loss or androgenic alopecia is a genetically predisposed disorder from altered response to androgen.
- However, pattern hair loss is seen to occur clinically even with normal androgen levels. Scientific updates have attributed hair loss to be inflammatory, immune-mediated, nutritional, genetic, and hormonal or from any imbalance causing dysregulation of the hair growth cycle.
- AGA is described as prolongation of telogen and shortening of anagen. Clinically, every alopecia begins as simple hair fall or telogen effluvium. Continued exposure to these non androgenic factors, promotes gradual cellular dysfunction and accumulation of ROS, which is proven to increase the sensitivity of androgen receptors (AR) making them hyper sensitive to normal circulating androgens, without any rise in androgen levels.
- ROS also trigger the release of inflammatory cytokines which further augment various AR sensitive pathways. Thus, the follicles have now become sensitive to normal androgens and DHT from relentless exposure to non androgenic factors.
- Nutrients are also responsible for secretion of hormones, neurotransmitters, chemical mediators, regulators of cell function, defense and immunity. Inability to keep up to these functions manifests as oxidative stress, compromised immune response, inability to counter inflammation, cellular aging and senescence. Hair being a tissue with a high metabolic rate, even a modest imbalance, affects the growth cycle converting mitosis to apoptosis.
- The stress hormone, cortisol, is known to affect the function and cycle regulation of the hair follicle. The term allostatic load refers to the effect of cumulative stress and life events on the immune, autonomic, neuroendocrine and metabolic systems. Nutrients, antioxidants, vitamins, minerals, omega 3 and amino acids play a role in improving these biomarkers and reducing stress.
- Stress causes nutritional imbalance, metabolic imbalance and insulin resistance.
- Hair growth during such adaptation is arrested in order to conserve the nutrients and redirect them to more important vital functions.
- Stress escalates physiological demand for energy, oxygen utilization, cellular functions, requiring enzymes, cofactors, catalysts and micronutrients.
- Secretion of glucocorticoids and cortisol is the first response to
physical, emotional or mental stress. This leads to excess glucose
conversion from proteins and fat to promote brain, muscles and nerve
response to flight, fight and fear.
Stress accelerates cell metabolism, raising nutrient requirement, increasing appetite, hunger craving for high sugar, high salt high fat comfort foods. - Higher metabolism generates more free radicals. These toxins weaken the cellular functions. Plus these ROS are mediators for the action of DHT. Substance P and influence genetic expression leading to hair loss in many ways.
Key Ingredients & Roles
With advantages of Lactoferrin, Quercetin, Docosahexanoic acid (DHA),
Melatonin, Moringa leaf extract, Calcium pantothenate etc.
Lactoferrin
It is an iron -binding glycoprotein found in body fluid
including milk, exerts effects on the stimulation of DP cell
proliferation and hair growth. Lactoferrin shows
anti-inflammatory, immune – boosting properties that prevents
hair loss
Quercetin
It stimulates hair growth with enhanced expression of growth
factors via activation of MAPK/CREB signaling pathway. It
inhibits the production of DHT from testosterone by blocking the
action of 5 alpha reductase enzymes which prevents balding of
the scalp in AGA.
Docosahexanoic acid (DHA)
It is an omega 3 fatty acids that not only increases cellular
proliferation. But also promotes hair growth through the anagen
– activating pathway in DPCS.
Melatonin
Melatonin regulates circadian rhythm cycle. It improves sleep
latency and sleep efficiency (The ratio of total sleep time in
bed). It protects premature hair greying by protecting stem
cells.
Moringa leaf extract
It’s the richest source of vitamins and minerals that activate
the dormant hair follicles that help in hair growth. It prevents
oxidative stress and insulin resistance.
Calcium pantothenate
It helps in cellular metabolism. Amino acids are precursors of
dopamine and tryptophan.
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