AGA - Thyroid
- Thyroid autoimmunity is well documented in alopecia areata. In androgenetic alopecia multilayered interactions between thyroid hormones and androgens may contribute to the development of alopecia. In females, significant hypophyseal hypothyroidism may play a role in androgenetic alopecia. High or low level of thyroid hormone contributes in diffuse alopecia and hair thinning.
- Pattern hair loss or androgenic alopecia is a genetically predisposed disorder from altered response to androgen.
- However, pattern hair loss is seen to occur clinically even with normal androgen levels. Scientific updates have attributed hair loss to be inflammatory, immune-mediated, nutritional, genetic, and hormonal or from any imbalance causing dysregulation of the hair growth cycle.
- AGA is described as prolongation of telogen and shortening of anagen. Clinically, every alopecia begins as simple hair fall or telogen effluvium. Continued exposure to these non androgenic factors, promotes gradual cellular dysfunction and accumulation of ROS, which is proven to increase the sensitivity of androgen receptors (AR) making them hyper sensitive to normal circulating androgens, without any rise in androgen levels.
- ROS also trigger the release of inflammatory cytokines which further augment various AR sensitive pathways. Thus, the follicles have now become sensitive to normal androgens and DHT from relentless exposure to non androgenic factors.
- Hormones are a sequence of poly peptides and micro nutrients. Dieting, stress, sleep, pollution, smoking, alcohol, all lead to generation of ROS increasing demand for antioxidant defense and adding to the deficiency in nutrient supply. Hence the use of well calculated synergistic supplements can reverse the deterioration of thyroid function, instead of depending on readymade hormone pills, which further make the gland functionless.
Key Ingredients & Roles
With the adventages of Kelp seaweed, Spirulina, Vitamin D3, Quercetin,
Beta-sitosterols, Lactoferrin etc.
Kelp seaweed
Iodine is needed for hormone production in the human body. Sea
kelp supplements provide essential iodine levels for regulating
the body’s hormone production.
Spirulina
Spirulina contains 70 % Protein, fatty acids and iron. Spirulina
also contains other constituents, such as (vitamin B complex,
minerals, selenium, iron, potassium, calcium, zinc and
magnesium).
The highly nutritious spirulina has hypolipidemic, hypoglycemic, anti inflammatory and immunostimulating effects.
The highly nutritious spirulina has hypolipidemic, hypoglycemic, anti inflammatory and immunostimulating effects.
Vitamin D3
Vitamin D3 Supplementation among hypothyroid patients for 12
weeks improved serum TSH and calcium concentration. It directly
stimulates hair growth from dermal papilla cells.
Quercetin
It stimulates hair growth with enhanced expression of growth
factors via activation of MAPK/CREB signaling pathway. It
inhibits the production of DHT from testosterone by blocking the
action of 5 alpha reductase enzymes which prevents balding of
the scalp in AGA.
Beta sitosterols
It is a plant – derived phytosterol, which blocks the conversion
of testosterone in to dihydrotestosterone (DHT) by inhibition of
5 alpha – reductase enzymes and helps in androgenic alopecia.
Its antioxidant activity counters ROS and stress – induced
alopecia. It also modifies prostaglandin pathways and T helper
cell- mediated immune response.
Lactoferrin
It is an iron -binding glycoprotein found in body fluid
including milk, exerts effects on the stimulation of DP cell
proliferation and hair growth. Lactoferrin shows
anti-inflammatory, immune – boosting properties that prevents
hair loss.
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